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The physical location of the DR site relative to the primary site is one of the most important considerations. It can t be too close or it could be affected by the very same disaster, but it can t be so far away that it is difficult or impossible to reach in all circumstances. In the days that followed September 11, 2001, the United States Federal Aviation Administration (FAA) took the unprecedented step of shutting down all air traffic in the United States. New York based businesses that wished to relocate their operations to a DR site could not fly there, and so if the site was more than a few hundred miles away, they could not get their people to the site. On the other hand, there are unverified stories of organizations who operated their primary site from one World Trade Center tower with their DR site in the other tower. Clearly that was too close. If a visit to the DR site requires any form of public transportation, it may be inaccessible in a disaster. If employees can drive there, they could easily get stuck in evacuation or panic-driven traffic jams.

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I know of at least one major New York financial institution whose DR site is in the bucolic New Jersey suburbs, roughly an hour s drive outside Manhattan under the best conditions. Although this site is manned 24 hours a day, seven days a week, if it were not, it would be necessary for their system administrators to make their way to this remote site after a disaster. If the system administrators live in Manhattan, it is extremely unlikely that they have cars, leaving them no way to get to the New Jersey suburbs in such circumstances. Evan

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long-term instability of the pH gradient that results from cathodic drift of the carrier ampholytes Even with these known disadvantages, carrier ampholyte-based IEF is capable of resolving proteins that differ in their pI values by only 002 pH unit The highest resolving power obtainable with IEF methods is achieved when immobilized pH gradients are used 114 IMMOBILIZED pH GRADIENTS (IPGs)9 Gradients of pH can be immobilized directly into a polyacrylamide gel backbone by casting a gradient from one type of monomer to another, where the monomer species employed have protolytic functional groups The buffering capacity is then held rigidly in place, and the pH gradient is generated during the gel casting process Figure 116 shows an apparatus that is used for casting gradient gels.

On the other hand, two sites located 300 miles apart along California s San Andreas Fault are not well insulated against a single disaster. Two sites along the North Carolina coast, even hundreds of miles apart, could both be taken out by the same hurricane.

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A common choice among Wall Street firms is to set up their DR site across the Hudson River in New Jersey, just a couple of miles away In many cases, you can actually see one building from the other Although this is a fairly common practice, it gives us cause for concern It is not hard to imagine certain types of disasters that might take out both locations Other things to keep in mind when considering DR site locations: Can you reach both sites from a single SAN If so, you can save a great deal of complexity and money by mirroring your data within the single SAN between disks located at each site.

The diffusion of acid and base into the gel from opposite ends converts the acidic and basic groups to their correct forms (salts are used during casting) A prefocusing step is not required with IPGs as it is with carrier ampholyte IEF Because of the control that is achievable during the casting of the gradient, linear pH gradients are readily constructed over very narrow pH ranges, allowing the resolution of proteins that differ in their pI values by only 0001 pH unit Examples of the monomeric species used to generate the IPG are shown in Table 111 These compounds are all acrylamide derivatives, have pK values well distributed over the pH 3 10 interval, and are mixed with the acrylamide monomer solutions prior to gel casting Note that these species are not amphoteric.

Or, as we discussed in 6, Backups and Restores, you could take tape backups from disks at one end of the SAN with tape drives at the other, automatically giving you off-site tapes that really aren t off-site at all Do the sites share utility services Are utilities such as electricity and telephone service provided by different companies at the two sites Or can a single mishap cause both your main site and your DR site to lose, say, electricity for an extended period of time Is the DR site near medical facilities This is a good idea all the time, not just when considering DR sites It s always better to be close to a hospital or other medical facility, but in times of crisis, it can be even more valuable.

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