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where [E S] is formed only from the association reaction, but is removed either by dissociation into E and S, or by conversion to product. The enzyme exists in solution as either E or E S, so that at any time, the total enzyme concentration is equal to the sum of these concentrations, or [E]0 [E] [E S]. Using this expression to substitute for [E] in Eq. 2.12 yields d E S =dt k1 E 0 E S S k 1 E S k2 E S 0 Rearranging to collect terms in [E S] yields Eqs. 2.14 and 2.15: k1 E 0 S k1 S k 1 k2 E S 0 E S E 0 S =f S k 1 k2 =k1 g 2:14 2:15 2:13

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nobody would ever be able to find the book, and if we let it stay, we would have the opportunity to define it ourselves So we left it in Think of it as a marketing decision If you ask around, you ll find that there really is no hard definition for high availability or a firm threshold that determines whether or not a particular system has achieved it Vendors have molded the term to fit their needs Just about every system and OS vendor with a marketing department claims to deliver high availability in one form or another The truth is that despite claims of 7 24 whatever, or some number of nines, those claims mean remarkably little in practical day-to-day system availability The Storage Network Industry Association (SNIA) has an excellent online technical dictionary (wwwsnia.

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org/dictionary), in which they define high availability as follows: The ability of a system to perform its function continuously (without interruption) for a significantly longer period of time than the reliabilities of its individual components would suggest High availability is most often achieved through failure tolerance High availability is not an easily quantifiable term Both the bounds of a system that is called highly available and the degree to which its availability is extraordinary must be clearly understood on a case-by-case basis1 It is a rare definition that admits its own vagueness So, in the hunt for the true definition of high availability, we must take a different approach Breaking the term into its components, we have High, adj Greater than normal in degree or amount Availability, n The quality of being at hand when needed2 Availability is pretty clearly defined, but it s high that is the problem.

Equation 2.15 can now be used to nd the initial rate of formation of product, as given in Eq. 2.16: n k2 E S k2 E 0 S =f S k 1 k2 =k1 g 2:16

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Is a 20-story building high In Manhattan, Kansas, it would be, but in Manhattan, New York, a 20-story building is lost in the crowd It s very much a relative term How high is up How up is high How available does something have to be for it to be highly available Greater than normal What is normal, and who defines it Again, not much help in these definitions Developing a practical definition for high availability will require still another approach Consider why someone implements a computer system Someone spends money to purchase (or lease) a computer system The goal, as it is with any business expenditure, is to get some sort of return, or value back, on that spending Money that is spent with the intent of getting value back is an investment.

The goal, then, is to achieve an appropriate return on the investment made to implement the computer system The return on that investment need not be.

Recalling that the maximum initial rate of reaction Vmax occurs when all available enzyme exists in the form of the enzyme substrate complex (i.e., [E S] [E]0),

www.snia.org/education/dictionary/h www.dictionary.com/cgi-bin/dict.pl (citing WordNet 1.6, 1997 Princeton University)

9 Choosing an Application Integration Solution 173 91 General approach 92 Methodology for calculating return on investment (ROI) 921 Introduction to the method 922 Equations: maintaining the language of integration 923 Operational workload gains through centralized supervision 924 Quality of service improvements 93 Opportunity study 931 Analyzing the real needs of the enterprise 932 Real needs and the state of the art 933 Identifying possible business benefits 94 Go/NoGo from General Management 95 The search for a candidate: Request for Information (RFI) 951 Why issue an RFI 952 Key points in an integration RFI ..

199 142 156 184 198

So, if every copy of the DR plan is a double-edged sword that can both save the company and destroy it, how do you handle document distribution Our recommendation is as follows:

(CH2)2N(CH3)2 (CH2)3N(CH3)2 (CH2)3N(CH2CH3)2 (CH2)2N(CH2CH3)3

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